By E F Patrice Jelliffe; Derrick B Jelliffe

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It is assumed that they act primarily by competitive inhibition of the' iodization of thyroxine. There is however little evidence that endemic goiter could be related to the consumption of goitrogenous food in man (Anonymous, 1968). , 1963). Interestingly, glucosinolates are particularly abundant in green leaves, and the use of various cabbage species for the production of leaf protein concentrates may therefore give rise to unexpected goitrogenous effects. Hemagglutinins are compounds of glucoprotein origin that affect the red blood corpuscles ultimately resulting in agglutination.

Vitamin E is a vitamin that is still said to be searching for its function. Although very few cases of vitamin E deficiency have so far been described in man, there is a widespread use of preparations containing the vitamin sometimes even in rather large doses. No certain toxic effects have however been observed, although there are reports of headache, nausea, fatigue, and blurred vision on high dosage vitamin E administration (King, 1949). u. u. u. (acne) 50 mg (against symptoms of oral contraceptives) 2,000-5,000 mg (hypercholesterolemi) Adapted from Hodges, 1976.

Phenylketonuria. Usually, the toxic effect is related to the special chemical and metabolic function and features of the amino acid(s) in question. Interestingly, it seems that the toxic effects are enhanced when the subject is given a low-protein diet. So far, toxic effects in humans have been described for methionine and the sulphur amino acids (Klavins and Peacocke, 1964), and for phenylalanine and tyrosine (Boctor and Harper, 1966). It has been postulated that the amino acids that are closely related metabolically seem to be more toxic than those that have only a few metabolic reactions in common (Salmon, 1958).

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